Mechanism of extracellular signal-regulated kinase activation by the CB(1) cannabinoid receptor.

@article{GalveRoperh2002MechanismOE,
  title={Mechanism of extracellular signal-regulated kinase activation by the CB(1) cannabinoid receptor.},
  author={Ismael Galve-Roperh and Daniel Rueda and Teresa G{\'o}mez del Pulgar and Guillermo Velasco and Manuel Guzm{\'a}n},
  journal={Molecular pharmacology},
  year={2002},
  volume={62 6},
  pages={
          1385-92
        }
}
Cannabinoids, the active components of marijuana and their endogenous counterparts, exert many of their actions in brain through the seven-transmembrane receptor CB(1). This receptor is coupled to the activation of the extracellular signal-regulated kinase (ERK) cascade. However, the precise molecular mechanism for CB(1)-mediated ERK activation is still unknown. Here, we show that in U373 MG human astrocytoma cells, CB(1) receptor activation with the cannabinoid agonist delta(8… 

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