Mechanism of extracellular signal-regulated kinase activation by the CB(1) cannabinoid receptor.
@article{GalveRoperh2002MechanismOE, title={Mechanism of extracellular signal-regulated kinase activation by the CB(1) cannabinoid receptor.}, author={Ismael Galve-Roperh and Daniel Rueda and Teresa G{\'o}mez del Pulgar and Guillermo Velasco and Manuel Guzm{\'a}n}, journal={Molecular pharmacology}, year={2002}, volume={62 6}, pages={ 1385-92 } }
Cannabinoids, the active components of marijuana and their endogenous counterparts, exert many of their actions in brain through the seven-transmembrane receptor CB(1). This receptor is coupled to the activation of the extracellular signal-regulated kinase (ERK) cascade. However, the precise molecular mechanism for CB(1)-mediated ERK activation is still unknown. Here, we show that in U373 MG human astrocytoma cells, CB(1) receptor activation with the cannabinoid agonist delta(8…
191 Citations
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Cannabinoid receptor signaling via G proteins results from interactions with the second, third and fourth intracellular loops of the receptor, and desensitization of signal transduction pathways that couple through the G proteins probably entails phosphorylation of critical amino acid residues on these intrACEllular surfaces.
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