Mechanism of extracellular ion exchange and binding-site occlusion in the sodium-calcium exchanger

@article{Liao2016MechanismOE,
  title={Mechanism of extracellular ion exchange and binding-site occlusion in the sodium-calcium exchanger},
  author={J. Liao and F. Marinelli and Changkeun Lee and Yihe Huang and J. Faraldo-G{\'o}mez and Youxing Jiang},
  journal={Nature structural \& molecular biology},
  year={2016},
  volume={23},
  pages={590 - 599}
}
Na+/Ca2+ exchangers use the Na+ electrochemical gradient across the plasma membrane to extrude intracellular Ca2+ and play a central role in Ca2+ homeostasis. Here, we elucidate their mechanisms of extracellular ion recognition and exchange through a structural analysis of the exchanger from Methanococcus jannaschii (NCX_Mj) bound to Na+, Ca2+ or Sr2+ in various occupancies and in an apo state. This analysis defines the binding mode and relative affinity of these ions, establishes the… Expand
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