Mechanism of extracellular domain-deleted dominant negative cadherins.

  title={Mechanism of extracellular domain-deleted dominant negative cadherins.},
  author={Marvin T. Nieman and Jae Bum Kim and Keith R. Johnson and Margaret J. Wheelock},
  journal={Journal of cell science},
  volume={112 ( Pt 10)},
The cadherin/catenin complex mediates Ca2+-dependent cell-cell interactions that are essential for normal developmental processes. It has been proposed that sorting of cells during embryonic development is due, at least in part, to expression of different cadherin family members or to expression of differing levels of a single family member. Expression of dominant-negative cadherins has been used experimentally to decrease cell-cell interactions in whole organisms and in cultured cells. In this… CONTINUE READING

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