Mechanism of extracellular ATP-induced depolarization in rat isolated ventricular cardiomyocytes

@article{Scamps1990MechanismOE,
  title={Mechanism of extracellular ATP-induced depolarization in rat isolated ventricular cardiomyocytes},
  author={Fr{\'e}d{\'e}rique Scamps and Guy Vassort},
  journal={Pfl{\"u}gers Archiv},
  year={1990},
  volume={417},
  pages={309-316}
}
Adenosine triphosphate (ATP) is released during neural stimulation and cardiac hypoxia and several mechanims of its action have been reported in different tissues. ATP stimulates P1 and P2 purinergic receptors; it also activates receptor-operated channels and increases membrane permeability to small ions. In single rat ventricular cells under whole-cell patch-clamp, a stepwise application of ATP in the micromolar range affects the resting potential and membrane currents through an entirely… CONTINUE READING
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ATP induces depolarization by increasing intracellalar free Ca + § and H +

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