Mechanism of extracellular ATP- and adenosine-induced apoptosis of cultured pulmonary artery endothelial cells.

@article{Rounds1998MechanismOE,
  title={Mechanism of extracellular ATP- and adenosine-induced apoptosis of cultured pulmonary artery endothelial cells.},
  author={Sharon I S Rounds and Winnie Lin Yee and Doloretta D. Dawicki and Elizabeth O Harrington and Nancy S Parks and Michael V Cutaia},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={1998},
  volume={275 2},
  pages={L379-L388}
}
Apoptosis may be important in the exacerbation of endothelial cell injury or limitation of endothelial cell proliferation. We have found that extracellular ATP (exATP) and adenosine cause endothelial apoptosis and that the development of apoptosis is linked to intracellular metabolism of adenosine [Dawicki, D. D., D. Chatterjee, J. Wyche, and S. Rounds. Am. J. Physiol. 273 ( Lung Cell Mol. Physiol. 17): L485-L494, 1997]. In the present study, we investigated the mechanism of this effect. We… CONTINUE READING