Mechanism of enhancement of radiation-induced cytotoxicity by sorafenib in colorectal cancer

Abstract

Sorafenib, an orally available multikinase inhibitor, combined with radiation has shown potential as an anticancer treatment in an in vitro and in vivo colon cancer model. In this study, we investigated the mechanism of enhancement of radiation-induced cytotoxicity by sorafenib in colorectal cancer. The effects of sorafenib on radiation-induced cytotoxicity… (More)
DOI: 10.1093/jrr/rrs074

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