Mechanism of efflux of noradrenaline from adrenergic nerves in rabbit atria.

@article{Paton1973MechanismOE,
  title={Mechanism of efflux of noradrenaline from adrenergic nerves in rabbit atria.},
  author={David M. Paton},
  journal={British journal of pharmacology},
  year={1973},
  volume={49 4},
  pages={614-27}
}
1. The mechanism of efflux of (-)-[(3)H]-noradrenaline was examined in rabbit atria, which were pretreated with reserpine and pargyline.2. Between 40 and 100 min, efflux occurred predominantly from a single intraneuronal compartment.3. Efflux was rapidy increased by (-)- and (+)-noradrenaline, tyramine and (+/-)-metaraminol, but not by (+/-)-isopropylnoradrenaline or (+/-)-normetanephrine. The increase in efflux produced by (-)-noradrenaline was inhibited by cocaine and desipramine but not by… CONTINUE READING

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