Mechanism of divergent growth factor effects in mesenchymal stem cell differentiation.

  title={Mechanism of divergent growth factor effects in mesenchymal stem cell differentiation.},
  author={Irina Kratchmarova and Blagoy Blagoev and Mandana Haack-Sorensen and Moustapha Kassem and Matthias Mann},
  volume={308 5727},
Closely related signals often lead to very different cellular outcomes. We found that the differentiation of human mesenchymal stem cells into bone-forming cells is stimulated by epidermal growth factor (EGF) but not platelet-derived growth factor (PDGF). We used mass spectrometry-based proteomics to comprehensively compare proteins that were tyrosine phosphorylated in response to EGF and PDGF and their associated partners. More than 90% of these signaling proteins were used by both ligands… CONTINUE READING
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