Mechanism of diuretic response to increased left atrial pressure in the anesthetized dog.

@article{Torrent1975MechanismOD,
  title={Mechanism of diuretic response to increased left atrial pressure in the anesthetized dog.},
  author={Antoine de Torrent{\'e} and Gary L. Robertson and Kent M. McDonald and Robert Schrier},
  journal={Kidney international},
  year={1975},
  volume={8 6},
  pages={355-61}
}
The mechanism whereby an increase in left atrial pressure (LAP) causes a water diuresis in the anesthetized dog remains controversial. In the present study LAP was increased by inflation of an atrial balloon in two groups of animals. In the first group of eight intact dogs, mean LAP was increased from 3.4 to 17.6 mm Hg (P less than 0.001). The rise in LAP was associated with a mean increase in urine flow (V) from 0.70 to 1.29 ml/min (P less than 0.001), a decrease in urinary osmolality (Uosm… CONTINUE READING