• Corpus ID: 31420336

Mechanism of diuretic action of U-62,066E, a kappa opioid receptor agonist.

@article{Yamada1989MechanismOD,
  title={Mechanism of diuretic action of U-62,066E, a kappa opioid receptor agonist.},
  author={K. Yamada and Masashi Imai and S Yoshida},
  journal={European journal of pharmacology},
  year={1989},
  volume={160 2},
  pages={
          229-37
        }
}
The mechanism of the diuretic action of U-62,066E, a highly selective kappa opioid agonist, was examined in unanesthetized rats and in isolated perfused inner medullary collecting ducts (IMCD). In Long-Evans rats, U-62,066E caused a dose-dependent increase in urine flow and a decrease in urine osmolality without affecting urinary excretion of Na+. The diuretic effect of U-62,066E was blocked by MR-2266, a kappa opioid receptor antagonist. U-62,066E showed no diuretic effect in homozygous… 
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