Mechanism of dexamethasone suppression of brain tumor-associated vascular permeability in rats. Involvement of the glucocorticoid receptor and vascular permeability factor.

@article{Heiss1996MechanismOD,
  title={Mechanism of dexamethasone suppression of brain tumor-associated vascular permeability in rats. Involvement of the glucocorticoid receptor and vascular permeability factor.},
  author={John D. Heiss and E Papavassiliou and Marsha J. Merrill and Lynnette K Nieman and J J Knightly and Stuart Walbridge and Nancy Adair Edwards and Edward H. Oldfield},
  journal={The Journal of clinical investigation},
  year={1996},
  volume={98 6},
  pages={
          1400-8
        }
}
Brain tumor-associated cerebral edema arises because tumor capillaries lack normal blood-brain barrier function; vascular permeability factor (VPF, also known as vascular endothelial growth factor, VEGF) is a likely mediator of this phenomenon. Clinically, dexamethasone reduces brain tumor-associated vascular permeability through poorly understood mechanisms. Our goals were to determine if suppression of permeability by dexamethasone might involve inhibition of VPF action or expression, and if… CONTINUE READING

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