Mechanism of depletion of liver glycogen in cancer cachexia.

@article{Hirai1997MechanismOD,
  title={Mechanism of depletion of liver glycogen in cancer cachexia.},
  author={Kouzo Hirai and Osamu Ishiko and Michael John Dr. Tisdale},
  journal={Biochemical and biophysical research communications},
  year={1997},
  volume={241 1},
  pages={
          49-52
        }
}
Mice transplanted with a cachexia-inducing colonic adenocarcinoma (MAC16) show a progressive decrease in liver glycogen in direct proportion to the loss of body weight. Such tumours elaborate a lipid mobilizing factor (LMF), which produces a dose-dependent stimulation, not only of adipocyte adenylate cyclase, but also of hepatocyte adenylate cyclase in a GTP-dependent manner. These results suggest that LMF has the capacity to initiate hepatic glycogenolysis through an increase in cyclic AMP. 
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 13 CITATIONS

Effect of the Chinese Medicine YangZheng XiaoJi on Reducing Fatigue in Mice with Orthotopic Transplantation of Colon Cancer

  • Evidence-based complementary and alternative medicine : eCAM
  • 2019
VIEW 1 EXCERPT
CITES BACKGROUND

Mechanisms of cancer cachexia.

  • Physiological reviews
  • 2009
VIEW 1 EXCERPT
CITES BACKGROUND

Targets in clinical oncology: the metabolic environment of the patient.

  • Frontiers in bioscience : a journal and virtual library
  • 2007
VIEW 2 EXCERPTS
CITES BACKGROUND

Similar Papers