Mechanism of depigmentation by hydroquinone.

@article{Jimbow1974MechanismOD,
  title={Mechanism of depigmentation by hydroquinone.},
  author={Kowichi Jimbow and Hiroto Obata and Madhu A. Pathak and Thomas B. Fitzpatrick},
  journal={The Journal of investigative dermatology},
  year={1974},
  volume={62 4},
  pages={
          436-49
        }
}
Histochemical (dopa reaction) and electron microscopic studies were carried out to elucidate the nature of the chemical depigmentation produced by hydroquinone (HQ). Depigmentation was induced by topical application or subcutaneous injection of HQ in black guinea pigs. The present study showed that HQ preferentially affected the nonfollicular and follicular melanocyte system. It caused decreased formation of melanosomes, a marked alteration in the internal structure of melanosomes, an increased… Expand
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TLDR
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