Mechanism of dengue virus broad cross-neutralization by a monoclonal antibody.


The dengue virus (DENV) complex is composed of four distinct but serologically related flaviviruses, which together cause the present-day most important emerging viral disease. Although DENV infection induces lifelong immunity against viruses of the same serotype, the antibodies raised appear to contribute to severe disease in cases of heterotypic… (More)
DOI: 10.1016/j.str.2012.01.001