Mechanism of degradation of CPEB during Xenopus oocyte maturation.

  title={Mechanism of degradation of CPEB during Xenopus oocyte maturation.},
  author={D. Setoyama and Masakane Yamashita and Noriyuki Sagata},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={104 46},
CPEB, a cytoplasmic polyadenylation element-binding protein, plays an important role in translational control of maternal mRNAs in early animal development. During Xenopus oocyte maturation, CPEB undergoes a Cdc2-mediated phosphorylation- and ubiquitin-dependent degradation that is required for proper entry into meiosis II. However, the precise mechanism of… CONTINUE READING