Mechanism of cytotoxicity of methylmercury. With special reference to microtubule disruption.

@article{Miura1989MechanismOC,
  title={Mechanism of cytotoxicity of methylmercury. With special reference to microtubule disruption.},
  author={Koh Miura and Nobumasa Imura},
  journal={Biological trace element research},
  year={1989},
  volume={21},
  pages={
          313-6
        }
}
Mechanism of methylmercury cytotoxicity was investigated with special reference to its preferential action on microtubules and protein biosynthesis in cultured cells. The tubulin synthesis analyzed by autoradiography of two-dimensional electropherogram using 35S-methionine was inhibited by 50-70% in mouse glioma cells exposed to 5 x 10(-6) M methylmercury for 3 h, which almost completely depolymerized microtubules. Total protein synthesis monitored by incorporation of labeled methionine into… CONTINUE READING