Mechanism of cytotoxicity of human large granular lymphocytes: relationship of the cytotoxic lymphocyte protein to the ninth component (C9) of human complement.

Abstract

A Mr 70,000 protein was isolated from cytotoxic human large granular lymphocytes and shown to have cytotoxic activity. The protein was demonstrated to be immunochemically related to the ninth component (C9) of complement and was therefore designated C9-related protein (C9RP). This finding suggests that C9RP and C9 share homology in primary structure and… (More)

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@article{Zalman1986MechanismOC, title={Mechanism of cytotoxicity of human large granular lymphocytes: relationship of the cytotoxic lymphocyte protein to the ninth component (C9) of human complement.}, author={Leora S Zalman and Michael Brothers and Fu-Hsuan Chiu and Hans J. M{\"u}ller-Eberhard}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1986}, volume={83 14}, pages={5262-6} }