Mechanism of cytotoxicity mediated by the C31 fragment of the amyloid precursor protein.

@article{Park2009MechanismOC,
  title={Mechanism of cytotoxicity mediated by the C31 fragment of the amyloid precursor protein.},
  author={Sun Ah Park and Gideon M. Shaked and Dale E. Bredesen and Edward H. Koo},
  journal={Biochemical and biophysical research communications},
  year={2009},
  volume={388 2},
  pages={450-5}
}
The cytoplasmic tail of the amyloid precursor protein (APP) contains two putatively cytotoxic peptides, Jcasp and C31, derived by caspase cleavage of APP. Jcasp is a fragment starting from the epsilon-secretase site to position 664, while C31 is a fragment from position 665 to the C-terminus. Our studies now showed that compared to C31, Jcasp appeared to play a minor role in cytotoxicity. In particular, inhibition of Jcasp generation by treatment of gamma-secretase inhibitor did not lead to any… CONTINUE READING

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