Mechanism of cytotoxic action of crambescidin-816 on human liver-derived tumour cells.

@article{Rubiolo2014MechanismOC,
  title={Mechanism of cytotoxic action of crambescidin-816 on human liver-derived tumour cells.},
  author={Juan Andr{\'e}s Rubiolo and Henar L{\'o}pez-Alonso and Mar{\'i}a Roel and Mercedes Rodr{\'i}guez Vieytes and Oliver Thomas and Eva Ternon and F{\'e}lix Victor Vega and Luis M. Botana},
  journal={British journal of pharmacology},
  year={2014},
  volume={171 7},
  pages={1655-67}
}
BACKGROUND AND PURPOSE Marine sponges have evolved the capacity to produce a series of very efficient chemicals to combat viruses, bacteria, and eukaryotic organisms. It has been demonstrated that several of these compounds have anti-neoplastic activity. The highly toxic sponge Crambe crambe has been the source of several molecules named crambescidins. Of these, crambescidin-816 has been shown to be cytotoxic for colon carcinoma cells. To further investigate the potential anti-carcinogenic… CONTINUE READING

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