Mechanism of cyclophosphamide transport by L5178Y lymphoblasts in vitro.

  title={Mechanism of cyclophosphamide transport by L5178Y lymphoblasts in vitro.},
  author={Gerald J. Goldenberg and Hartmut Land and D V Cormack},
  journal={Cancer research},
  volume={34 12},
Mechanism of transport of the alkylating agent cyclophos phamide-' 4C was investigated in L5 178Y lymphoblasts in vitro. A time course of cyclophosphamide uptake showed a rapid, initial phase, probably due to binding of drug to the cell surface. Subsequent uptake into the cells was carrier mediated and consisted of two components. Analysis of cyclophos phamide uptake over a 40-fold range of drug concentration showed biphasic kinetics with evidence of saturation only at low drug concentrations… CONTINUE READING


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