Mechanism of coronary microvascular responses to metabolic stimulation.

  title={Mechanism of coronary microvascular responses to metabolic stimulation.},
  author={Richard P Embrey and Leonard A Brooks and Kevin C. Dellsperger},
  journal={Cardiovascular research},
  volume={35 1},
UNLABELLED Previous studies from our laboratory have shown that coronary microvascular dilation to increased myocardial oxygen consumption (MVO2) is greater in vessels < 100 microns. The mechanism responsible for this response is uncertain. OBJECTIVES We tested the hypothesis that microvascular dilation to increased MVO2 is mediated by nitric oxide (NO). Since NO release may occur in response to increased shear, we also tested the hypothesis that metabolic byproducts released in response to… CONTINUE READING


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