Mechanism of contracture on cooling of caffeine-treated frog skeletal muscle fibres.

@article{Horiuti1988MechanismOC,
  title={Mechanism of contracture on cooling of caffeine-treated frog skeletal muscle fibres.},
  author={Keisuke Horiuti},
  journal={The Journal of physiology},
  year={1988},
  volume={398},
  pages={131-48}
}
1. In order to clarify the mechanism of contracture on cooling of caffeine-treated intact muscle fibres, the temperature dependence of a calcium (Ca2+) release mechanism, 'Ca2+-induced Ca2+ release', of the sarcoplasmic reticulum (SR) was examined in skinned frog muscle fibres. 2. Skinned fibres in a solution containing 1.2 mM-caffeine and 0.7 mM-EGTA (Mg2+, 1.5 mM, Mg-ATP, 3.5 mM, pH 7), contracted on cooling (from 22 to 2 degrees C) due to Ca2+ release from the SR. 3. The rate of Ca2+ release… CONTINUE READING
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