Mechanism of constitutive export from the golgi: bulk flow via the formation, protrusion, and en bloc cleavage of large trans-golgi network tubular domains.

@article{Polishchuk2003MechanismOC,
  title={Mechanism of constitutive export from the golgi: bulk flow via the formation, protrusion, and en bloc cleavage of large trans-golgi network tubular domains.},
  author={Elena V. Polishchuk and Alessio Di Pentima and Alberto Luini and Roman S. Polishchuk},
  journal={Molecular biology of the cell},
  year={2003},
  volume={14 11},
  pages={
          4470-85
        }
}
Transport of constitutive cargo proteins from the Golgi complex to the plasma membrane (PM) is known to be mediated by large tubular-saccular carriers moving along microtubules. However, the process by which these large structures emerge from the trans-Golgi network (TGN) remains unclear. Here, we address the question of the formation of Golgi-to-PM carriers (GPCs) by using a suitable cluster of morphological techniques, providing an integrated view of their dynamics and three-dimensional… CONTINUE READING

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