Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain


Internal tandem duplication (ITD) of the juxtamembrane (JM) domain of FLT3 is the most frequent mutation in human acute myeloid leukemia, and is significantly associated with leukocytosis and a poor prognosis. Previously we reported that FLT3 with ITD (FLT3/ITD) formed a homodimer and was autophosphorylated on tyrosine residues, while the mechanism remains… (More)
DOI: 10.1038/sj.onc.1205332


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