Mechanism of citrinin-induced dysfunction of mitochondria. III. Effects on renal cortical and liver mitochondrial swelling.

@article{Chagas1995MechanismOC,
  title={Mechanism of citrinin-induced dysfunction of mitochondria. III. Effects on renal cortical and liver mitochondrial swelling.},
  author={Generoso M. Chagas and Maria Benigna Martinelli Oliveira and A. de P. Campello and Michael Kl{\"u}ppel},
  journal={Journal of applied toxicology : JAT},
  year={1995},
  volume={15 2},
  pages={91-5}
}
The effects of the mycotoxin citrinin on renal cortical and liver mitochondrial swelling were studied. Citrinin decreases the rate of swelling induced by the valinomycin-K+ complex, suggesting that the mycotoxin interferes with the mitochondrial membrane fluidity. Citrinin promotes reduction of the amplitude of swelling in the presence of Na+ ions. This alteration reflects interference with complex I of the respiratory chain and ATP synthase complex activity without disarranging the inner… CONTINUE READING

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