Mechanism of citrinin-induced dysfunction of mitochondria. II. Effect on respiration, enzyme activities, and membrane potential of liver mitochondria.

@article{Chagas1992MechanismOC,
  title={Mechanism of citrinin-induced dysfunction of mitochondria. II. Effect on respiration, enzyme activities, and membrane potential of liver mitochondria.},
  author={Generoso M. Chagas and Benigna Maria de Oliveira and A. de P. Campello and Michael Kl{\"u}ppel},
  journal={Cell biochemistry and function},
  year={1992},
  volume={10 3},
  pages={209-16}
}
The mycotoxin citrinin, depressed the phosphorylation efficiency of liver mitochondria as deduced from a decrease of respiratory coefficient and of the ADP/O ratio. Citrinin (1.0 mM) inhibited some enzymes linked to the respiratory chain, namely NADH oxidase and NADH cytochrome c reductase involved with complex I. The activities of enzymes related with other enzymatic complexes of the respiratory chain were either unaffected or enhanced. ATPase activity was inhibited by the mycotoxin. Malate… CONTINUE READING

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