Mechanism of chromosome exchange formation in human fibroblasts: insights from "chromosome painting".

@article{Brown1993MechanismOC,
  title={Mechanism of chromosome exchange formation in human fibroblasts: insights from "chromosome painting".},
  author={Janice M. Y. Brown and James W. Evans and Mary S Kovacs},
  journal={Environmental and molecular mutagenesis},
  year={1993},
  volume={22 4},
  pages={218-24}
}
We have used the techniques of premature chromosome condensation (PCC) and fluorescence in situ hybridization (FISH) with a library for human chromosome 4 to analyze the rate of rejoining of chromosome breaks and development of exchange aberrations in AG1522 human fibroblasts. AG1522 cells were irradiated in plateau phase with 10 Gy and fused with mitotic HeLa cells either immediately after irradiation or at intervals up to eight days later. The slides were then hybridized with the chromosome 4… CONTINUE READING
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