Mechanism of chloroform-induced renal toxicity: non-involvement of hepatic cytochrome P450-dependent metabolism.

@article{Fang2008MechanismOC,
  title={Mechanism of chloroform-induced renal toxicity: non-involvement of hepatic cytochrome P450-dependent metabolism.},
  author={Cheng Fang and Melissa Behr and Fang Xie and Shijun Lu and Meghan Doret and Hongxiu Luo and Weizhu Yang and Kenneth M. Aldous and Xinxin Ding and Jun Gu},
  journal={Toxicology and applied pharmacology},
  year={2008},
  volume={227 1},
  pages={48-55}
}
Chloroform causes hepatic and renal toxicity in a number of species. In vitro studies have indicated that chloroform can be metabolized by P450 enzymes in the kidney to nephrotoxic intermediate, although direct in vivo evidence for the role of renal P450 in the nephrotoxicity has not been reported. This study was to determine whether chloroform renal toxicity persists in a mouse model with a liver-specific deletion of the P450 reductase (Cpr) gene (liver-Cpr-null). Chloroform-induced renal… CONTINUE READING

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