Mechanism of chloride interaction with neurotransmitter:sodium symporters

@article{Zomot2007MechanismOC,
  title={Mechanism of chloride interaction with neurotransmitter:sodium symporters},
  author={Elia Zomot and Annie Bendahan and Matthias Quick and Yongfang Zhao and Jonathan A. Javitch and Baruch I. Kanner},
  journal={Nature},
  year={2007},
  volume={449},
  pages={726-730}
}
Neurotransmitter:sodium symporters (NSS) have a critical role in regulating neurotransmission and are targets for psychostimulants, anti-depressants and other drugs. Whereas the non-homologous glutamate transporters mediate chloride conductance, in the eukaryotic NSS chloride is transported together with the neurotransmitter. In contrast, transport by the bacterial NSS family members LeuT, Tyt1 and TnaT is chloride independent. The crystal structure of LeuT reveals an occluded binding pocket… 

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