Mechanism of cell detachment from temperature-modulated, hydrophilic-hydrophobic polymer surfaces.

@article{Okano1995MechanismOC,
  title={Mechanism of cell detachment from temperature-modulated, hydrophilic-hydrophobic polymer surfaces.},
  author={Tadashi Okano and Naohiro Yamada and Masakuni Umezono Ch Okuhara and Hiromi Sakai and Yoshiharua Sakurai},
  journal={Biomaterials},
  year={1995},
  volume={16 4},
  pages={
          297-303
        }
}
Poly(N-isopropylacrylamide) (PIPAAm), exhibiting a lower critical solution temperature (LCST) at 25 degrees C in physiological phosphate buffered saline solution (pH 7.4) and at 32 degrees C in pure water, was grafted onto the surfaces of commercial polystyrene cell culture dishes. This PIPAAm-grafted surface exhibited hydrophobic surface properties at temperatures over the LCST and hydrophilic surface properties below the LCST. Endothelial cells and hepatocytes attached and proliferated on… CONTINUE READING
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