Mechanism of cell death induced by spermine and amine oxidase in mouse melanoma cells.

  title={Mechanism of cell death induced by spermine and amine oxidase in mouse melanoma cells.},
  author={Diana A. Averill-Bates and Qixiang Ke and Andr{\'e} Tanel and Julie A. Roy and Guy Fortier and Enzo Agostinelli},
  journal={International journal of oncology},
  volume={32 1},
Polyamines such as spermine, spermidine and putrescine are necessary for cell proliferation and are detected at higher concentrations in most tumor tissues, compared to normal tissues. The amine oxidase enzymes can generate cytotoxic products such as hydrogen peroxide and aldehydes from these polyamines. This study investigates the mechanisms of cell death in B16-F0 mouse melanoma tumor cells exposed to bovine serum amine oxidase and exogenous spermine. The bovine serum amine oxidase/spermine… 

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