Mechanism of cardiac involvement in the WBN/Kob rat.

  title={Mechanism of cardiac involvement in the WBN/Kob rat.},
  author={Shunsuke Tsuruta and Takashi Sutani and Jyun-ichi Masuda and Yoshihide Sakaguchi and Miyuki Tsuchihashi and Toshio Hashimoto and Yasuyuki Nakamura and Kaoru Dohi},
  journal={Journal of molecular and cellular cardiology},
  volume={29 1},
The cardiac characteristics of the WBN/Kob rat resemble those of rats with catecholamine-induced myocarditis. To determine the etiology of these WBN cardiac characteristics, we assessed the number and affinity of beta-adrenergic receptors, and investigated adenylate cyclase activity, the cardiac myocyte cyclic adenosine monophosphate (cAMP) concentration and the activity of guanosine triphosphate (GTP)-binding protein in 3-month-old WBN/Kob rats. Age-matched Wistar rats served as controls. The… CONTINUE READING
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