Corpus ID: 23999667

Mechanism of cardiac T-type Ca channel blockade by amiloride.

  title={Mechanism of cardiac T-type Ca channel blockade by amiloride.},
  author={J. Tytgat and J. Vereecke and E. Carmeliet},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={254 2},
Whole cell clamp experiments were used to study the mechanism of action of amiloride on cardiac T-type Ca channels in guinea pig ventricular myocytes. Two hundred fifty microM amiloride blocked the T-type Ca channel for approximately 50%, whereas this concentration did not suppress the L-type Ca channel. The Kd value for the block of the T-type Ca channel was 233 microM and the Hill coefficient was 1.1. The drug showed a rapid onset of action and a quick wash out with complete reversibility… Expand
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