Mechanism of cancer pain.

@article{Schmidt2010MechanismOC,
  title={Mechanism of cancer pain.},
  author={Brian L. Schmidt and Darryl T. Hamamoto and Donald A. Simone and George L. Wilcox},
  journal={Molecular interventions},
  year={2010},
  volume={10 3},
  pages={
          164-78
        }
}
Ongoing and breakthrough pain is a primary concern for the cancer patient. Although the etiology of cancer pain remains unclear, animal models of cancer pain have allowed investigators to unravel some of the cancer-induced neuropathologic processes that occur in the region of tumor growth and in the dorsal horn of the spinal cord. Within the cancer microenvironment, cancer and immune cells produce and secrete mediators that activate and sensitize primary afferent nociceptors. Pursuant to these… CONTINUE READING

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