Mechanism of calcium transport stimulated by chlorothiazide in mouse distal convoluted tubule cells.

@article{Gesek1992MechanismOC,
  title={Mechanism of calcium transport stimulated by chlorothiazide in mouse distal convoluted tubule cells.},
  author={Frank A. Gesek and P. A. Friedman},
  journal={The Journal of clinical investigation},
  year={1992},
  volume={90 2},
  pages={429-38}
}
Thiazide diuretics inhibit Na+ and stimulate Ca2+ absorption in renal distal convoluted tubules. Experiments were performed on immortalized mouse distal convoluted tubule (MDCT) cells to determine the mechanism underlying the dissociation of sodium from calcium transport and the stimulation of calcium absorption induced by thiazide diuretics. Control rates of 22Na+ uptake averaged 272 +/- 35 nmol min-1 mg protein-1 and were inhibited 40% by chlorothiazide (CTZ, 10(-4) M). Control rates of 36Cl… CONTINUE READING

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