Mechanism of calcium gating in small-conductance calcium-activated potassium channels

  title={Mechanism of calcium gating in small-conductance calcium-activated potassium channels},
  author={X.-M. Xia and Bernd Fakler and Andre F. Rivard and Gary A. Wayman and Teresa R. Johnson-Pais and J. E. Keen and Takahiro Ishii and Birgit Hirschberg and Chris T. Bond and Serghey Lutsenko and James Maylie and John P Adelman},
The slow afterhyperpolarization that follows an action potential is generated by the activation of small-conductance calcium-activated potassium channels (SK channels). The slow afterhyperpolarization limits the firing frequency of repetitive action potentials (spike-frequency adaption) and is essential for normal neurotransmission. SK channels are voltage-independent and activated by submicromolar concentrations of intracellular calcium. They are high-affinity calcium sensors that transduce… CONTINUE READING
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