Mechanism of calcium current modulation underlying presynaptic facilitation and behavioral sensitization in Aplysia.

@article{Klein1980MechanismOC,
  title={Mechanism of calcium current modulation underlying presynaptic facilitation and behavioral sensitization in Aplysia.},
  author={Marc Klein and Eric R Kandel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1980},
  volume={77 11},
  pages={6912-6}
}
Behavioral sensitization of the gill-withdrawal reflex of Aplysia is caused by presynaptic facilitation at the synapses of the mechanoreceptor sensory neurons of the reflex onto the motor neurons and interneurons. The presynaptic facilitation has been shown to be simulated by serotonin (the putative presynaptic facilitatory transmitter) and by cyclic AMP and to be accompanied by an increase in the Ca2+ current of sensory neuron cell bodies exposed to tetraethylammonium. This increase in the Ca2… CONTINUE READING
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