Mechanism of caffeine-induced arrhythmias in canine cardiac Purkinje fibers.


The effects of caffeine were studied in canine cardiac Purkinje fibers perfused in vitro. The study revealed that (1) caffeine induces an oscillatory potential (Vos) superimposed on early diastolic depolarization in driven fibers; (2) Vos magnitude increases (within limits) with the concentration of caffeine (0.5 to 3 mM) and as a function of time of… (More)


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