Mechanism of cadmium-decreased glucuronidation in the rat.

@article{Alary1992MechanismOC,
  title={Mechanism of cadmium-decreased glucuronidation in the rat.},
  author={Jacques Alary and Jean-Pierre Cravedi and Maryse Baradat and G. Carrera},
  journal={Biochemical pharmacology},
  year={1992},
  volume={44 11},
  pages={
          2139-47
        }
}
Metabolism and Cytotoxicity of Chlorpropham (CIPC) and Its Essential Metabolites in Isolated Rat Hepatocytes During a Partial Inhibition of Sulphation and Glucuronidation Reactions: A Comparative Study
TLDR
A combined effect of free 4-OH CIPC and D-galactosamine on intracellular ATP level that could account for the partial inhibition of sulphation is demonstrated.
Differential inhibition of morphine glucuronidation in the 3- and 6-position by ranitidine in isolated hepatocytes from guinea pig.
TLDR
The observation that the present effect on morphine glucuronidation was the opposite of that observed when administering a known co-substrate (UDPGA) depletor indicated that in all probability the effect of ranitidine was a direct inhibition on the uridine 5'-diphosphate glucuronyltransferases involved, with a more pronounced effect for the isoenzymes responsible for the 3'-glucuronidation.
Morphine Glucuronidation and Glucosidation Represent Complementary Metabolic Pathways That Are Both Catalyzed by UDP-Glucuronosyltransferase 2B7: Kinetic, Inhibition, and Molecular Modeling Studies
TLDR
Overall, the data indicate that morphine glucuronidation and glucosidation occur as complementary metabolic pathways catalyzed by a common enzyme (UGT2B7).
GALACTOSAMINE PREVENTS ETHINYLESTRADIOL-INDUCED CHOLESTASIS
Ethinylestradiol (EE) induces intrahepatic cholestasis in experimental animals being its derivative, ethinylestradiol 17β-glucuronide, a presumed mediator of this effect. To test whether
Chlorpropham [isopropyl N-(3-chlorophenyl) carbamate] disrupts microtubule organization, cell division, and early development of sea urchin embryos.
  • J. Holy
  • Biology
    Journal of toxicology and environmental health. Part A
  • 1998
TLDR
Results indicate that CIPC may pose a significant health risk during mammalian embryogenesis; in addition, it may be a useful tool with which to study microtubule and centrosomal functioning during animal cell division-especially in those cell types that exhibit stereotypic patterns of cell division during early development.
On the mechanisms of cadmium stress alleviation in Medicago truncatula by arbuscular mycorrhizal symbiosis: A root proteomic study
TLDR
The results indicated that part of the symbiotic program, which displays low sensitivity to Cd, may be recruited to counteract Cd toxicity through the mycorrhiza‐dependent synthesis of proteins having functions putatively involved in alleviating oxidative damages.

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