Mechanism of cadmium-decreased glucuronidation in the rat.

  title={Mechanism of cadmium-decreased glucuronidation in the rat.},
  author={Jacques Alary and Jean-Pierre Cravedi and Maryse Baradat and G. Carrera},
  journal={Biochemical pharmacology},
  volume={44 11},
Metabolism and Cytotoxicity of Chlorpropham (CIPC) and Its Essential Metabolites in Isolated Rat Hepatocytes During a Partial Inhibition of Sulphation and Glucuronidation Reactions: A Comparative Study
A combined effect of free 4-OH CIPC and D-galactosamine on intracellular ATP level that could account for the partial inhibition of sulphation is demonstrated.
Differential inhibition of morphine glucuronidation in the 3- and 6-position by ranitidine in isolated hepatocytes from guinea pig.
The observation that the present effect on morphine glucuronidation was the opposite of that observed when administering a known co-substrate (UDPGA) depletor indicated that in all probability the effect of ranitidine was a direct inhibition on the uridine 5'-diphosphate glucuronyltransferases involved, with a more pronounced effect for the isoenzymes responsible for the 3'-glucuronidation.
Morphine Glucuronidation and Glucosidation Represent Complementary Metabolic Pathways That Are Both Catalyzed by UDP-Glucuronosyltransferase 2B7: Kinetic, Inhibition, and Molecular Modeling Studies
Overall, the data indicate that morphine glucuronidation and glucosidation occur as complementary metabolic pathways catalyzed by a common enzyme (UGT2B7).
Ethinylestradiol (EE) induces intrahepatic cholestasis in experimental animals being its derivative, ethinylestradiol 17β-glucuronide, a presumed mediator of this effect. To test whether
Chlorpropham [isopropyl N-(3-chlorophenyl) carbamate] disrupts microtubule organization, cell division, and early development of sea urchin embryos.
  • J. Holy
  • Biology
    Journal of toxicology and environmental health. Part A
  • 1998
Results indicate that CIPC may pose a significant health risk during mammalian embryogenesis; in addition, it may be a useful tool with which to study microtubule and centrosomal functioning during animal cell division-especially in those cell types that exhibit stereotypic patterns of cell division during early development.
On the mechanisms of cadmium stress alleviation in Medicago truncatula by arbuscular mycorrhizal symbiosis: A root proteomic study
The results indicated that part of the symbiotic program, which displays low sensitivity to Cd, may be recruited to counteract Cd toxicity through the mycorrhiza‐dependent synthesis of proteins having functions putatively involved in alleviating oxidative damages.


Chemically-induced alteration of UDP-glucuronic acid concentration in rat liver.
  • J. Watkins, C. Klaassen
  • Chemistry, Biology
    Drug metabolism and disposition: the biological fate of chemicals
  • 1983
Since many xenobiotics alter hepatic UDP-glucuronosyltransferase activity, their effect on UDPGA concentration was determined. Rats were pretreated with: 1) microsomal enzyme inducers
The effects of sulfhydryl reacting agents on hepatic UDP-glucuronyltransferase in vitro.
  • A. Winsnes
  • Biology, Computer Science
    Biochimica et biophysica acta
  • 1971
Studies on the activation in vitro of glucuronyltransferase.
  • A. Winsnes
  • Biology, Computer Science
    Biochimica et biophysica acta
  • 1969
Purification of Rat-Liver Microsomal UDP-glucuronyltransferase
The results suggest the presence of at least two forms of UDP-glucuronyltransferase in rat liver, and factors affecting enzyme activity in purified and membrane-bound states are discussed.