Mechanism of bronchodilator effect in chronic airflow limitation.

  title={Mechanism of bronchodilator effect in chronic airflow limitation.},
  author={Roman C Jaeschke and Gordon H. Guyatt and Joel Singer and Jill Leslie Keller and Michael T. Newhouse},
  journal={CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne},
  volume={144 1},
OBJECTIVE To examine the mechanisms through which two bronchodilators (theophylline and salbutamol) influence dyspnea during daily activities. METHODS Twenty-four patients with chronic airflow limitation participated in a multiple crossover, randomized, placebo-controlled trial. The effect of theophylline and salbutamol, alone or combined, on pulmonary function and dyspnea during daily activities was examined. Correlations of changes in forced expiratory volume in 1 second (FEV1) and maximum… CONTINUE READING