Mechanism of bradykinin-induced venodilation in humans.

  title={Mechanism of bradykinin-induced venodilation in humans.},
  author={William D Dachman and Gary A. Ford and Terrence F. Blaschke and Brian B. Hoffman},
  journal={Journal of cardiovascular pharmacology},
  volume={21 2},
Bradykinin, a nonapeptide, dilates vascular smooth muscle at least in part via endothelial cell-dependent mechanisms. The aim of this study was to examine the action of bradykinin in human veins in vivo. Utilizing the dorsal hand vein technique, dose-response curves to bradykinin (maximum dose = 513 ng/min) were constructed in veins preconstricted with the alpha-adrenergic agonist phenylephrine in healthy young volunteers. Bradykinin almost fully dilated the veins back to their baseline… CONTINUE READING


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