Mechanism of bracken fern carcinogenesis: evidence for H-ras activation via initial adenine alkylation by ptaquiloside.

@article{Prakash1996MechanismOB,
  title={Mechanism of bracken fern carcinogenesis: evidence for H-ras activation via initial adenine alkylation by ptaquiloside.},
  author={Arungundrum S Prakash and Ta{\'i}se Pereira and Bettye L. Smith and Gillian M Shaw and Alan A. Seawright},
  journal={Natural toxins},
  year={1996},
  volume={4 5},
  pages={221-7}
}
Bracken fern (Pteridium spp.) causes cancer of the oesophagus and the urinary bladder in cattle and sheep. Ptaquiloside (PT) is believed to be the carcinogenic principle which alkylates DNA when activated to its unstable dienone form (APT) under alkaline conditions. In this report we present evidence for the presence of PT-DNA adducts in the ileum of bracken fem-fed calves using the 32P-postlabelling assay. H-ras mutations were also observed in the ileum using single strand conformation… CONTINUE READING
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