Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part 3: A novel mechanism for the inhibition of biological membrane lipid peroxidation by dioxygenated 4-methylcoumarins mediated by the formation of a stable ADP-Fe-inhibitor mixed ligand complex.

@article{Raj1998MechanismOB,
  title={Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part 3: A novel mechanism for the inhibition of biological membrane lipid peroxidation by dioxygenated 4-methylcoumarins mediated by the formation of a stable ADP-Fe-inhibitor mixed ligand complex.},
  author={Hanumantharao Guru Raj and Rajendra K. Sharma and Bhagwan Singh Garg and Virinder Singh Parmar and Subhash Chand Jain and Sanjay Goel and Yogesh Kumar Tyagi and Amarjit Singh and Carl Erik Olsen and Jesper Wengel},
  journal={Bioorganic & medicinal chemistry},
  year={1998},
  volume={6 11},
  pages={2205-12}
}
7,8-Dihydroxy-4-methylcoumarin (DHMC) and 7,8-diacetoxy-4-methylcoumarin (DAMC) have been reported to effectively inhibit in-vivo lipid peroxidation in rat tissues induced by CCl4 and paraquat. DHMC was found to readily impart green colour to the lipid peroxidation incubation mixture containing ADP and Fe3+, whereas DAMC formed green complex only upon incubation with liver microsomes, confirming our earlier observation that liver microsomal deacetylase hydrolyses DAMC to DHMC. Sensitive pH… CONTINUE READING