Mechanism of binding of fluoroquinolones to the quinolone resistance-determining region of DNA gyrase: towards an understanding of the molecular basis of quinolone resistance.

@article{Madurga2008MechanismOB,
  title={Mechanism of binding of fluoroquinolones to the quinolone resistance-determining region of DNA gyrase: towards an understanding of the molecular basis of quinolone resistance.},
  author={Sergio Madurga and Javier S{\'a}nchez-C{\'e}spedes and Ignasi Belda and Jordi Vil{\`a} and Ernest Giralt},
  journal={Chembiochem : a European journal of chemical biology},
  year={2008},
  volume={9 13},
  pages={2081-6}
}
We have studied the bacterial resistance to fluoroquinolones that arises as a result of mutations in the DNA gyrase target protein. Although it is known that DNA gyrase is a target of quinolone antibacterial agents, the molecular details of the quinolone-gyrase interaction remain unclear. The mode of binding of ciprofloxacin, levofloxacin, and moxifloxacin to DNA gyrase was analyzed by means of docking calculations over the surface of the QRDR of GyrA. The analysis of these binding models… CONTINUE READING