Mechanism of autooxidation for hemoglobins and myoglobins. Promotion of superoxide production by protons and anions.

@article{Wallace1982MechanismOA,
  title={Mechanism of autooxidation for hemoglobins and myoglobins. Promotion of superoxide production by protons and anions.},
  author={W J Wallace and R A Houtchens and James Clerk Maxwell and Winslow S. Caughey},
  journal={The Journal of biological chemistry},
  year={1982},
  volume={257 9},
  pages={4966-77}
}
Several hemoglobins and bovine myoglobin are shown to undergo autooxidation reactions promoted by anions. The reduced protein in the presence of oxygen and anion yields the anion complex of the oxidized (Met) species and a second product that is almost certainly superoxide. The second product can be detected by its reduction of cytochrome c3+ at the same rates and in the same amount as the Met species. Anions are increasingly effective as promoters in the same order as their strengths as… CONTINUE READING

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