Mechanism of asymmetric ovarian development in chick embryos.

@article{Ishimaru2008MechanismOA,
  title={Mechanism of asymmetric ovarian development in chick embryos.},
  author={Yoshiyasu Ishimaru and Tomoko Komatsu and Megumi Kasahara and Yuko Katoh-Fukui and Hidesato Ogawa and Yoshiro Toyama and Mamiko Maekawa and Kiyotaka Toshimori and Roshantha A. S. Chandraratna and Ken-ichirou Morohashi and Hidefumi Yoshioka},
  journal={Development},
  year={2008},
  volume={135 4},
  pages={677-85}
}
In most animals, the gonads develop symmetrically, but most birds develop only a left ovary. A possible role for estrogen in this asymmetric ovarian development has been proposed in the chick, but the mechanism underlying this process is largely unknown. Here, we identify the molecular mechanism responsible for this ovarian asymmetry. Asymmetric PITX2 expression in the left presumptive gonad leads to the asymmetric expression of the retinoic-acid (RA)-synthesizing enzyme, RALDH2, in the right… CONTINUE READING
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