Mechanism of arylating quinone toxicity involving Michael adduct formation and induction of endoplasmic reticulum stress.

@article{Wang2006MechanismOA,
  title={Mechanism of arylating quinone toxicity involving Michael adduct formation and induction of endoplasmic reticulum stress.},
  author={Xinhe Wang and Beena Rachel Thomas and Rakesh Sachdeva and Linnea Arterburn and Lucy Frye and P. Hatcher and D. Cornwell and Jiyan Ma},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 10},
  pages={
          3604-9
        }
}
Quinones permeate our biotic environment, contributing to both homeostasis and cytotoxicity. All quinones generate reactive oxygen species through redox cycling, while partially substituted quinones also undergo arylation (Michael adduct formation) yielding covalent bonds with nucleophiles such as cysteinyl thiols. In contrast to reactive oxygen species, the role of arylation in quinone cytotoxicity is not well understood. We found that the arylating quinones, including unsubstituted 1,4… CONTINUE READING

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