Mechanism of apoptosis induced by a lysosomotropic agent, L-Leucyl-L-Leucine methyl ester

@article{Uchimoto1999MechanismOA,
  title={Mechanism of apoptosis induced by a lysosomotropic agent, L-Leucyl-L-Leucine methyl ester},
  author={Takayuki Uchimoto and Hiroyuki Nohara and Rieko Kamehara and Michiko Iwamura and Naoko Watanabe and Yoshiro Kobayashi},
  journal={Apoptosis},
  year={1999},
  volume={4},
  pages={357-362}
}
Lysosomes are fundamental for cell growth, and thus inhibition of the lysosomal function often leads to cell death. L-Leucyl-L-leucine methyl ester (LeuLeuOMe) is a lysosomotropic agent that induces apoptosis of certain immune cells. LeuLeuOMe is taken up through receptor-mediated endocytosis, and then converted into (LeuLeu)n-OMe (n>3) by dipeptidyl peptidase I (DPPI) in lysosomes, which reportedly causes rupture of the lysosomes and DNA fragmentation. In this study we examined how lysosomal… CONTINUE READING