Mechanism of and exquisite selectivity for O-O bond formation by the heme-dependent chlorite dismutase.


Chlorite dismutase (Cld) is a heme b-dependent, O-O bond forming enzyme that transforms toxic chlorite (ClO(2)(-)) into innocuous chloride and molecular oxygen. The mechanism and specificity of the reaction with chlorite and alternate oxidants were investigated. Chlorite is the sole source of dioxygen as determined by oxygen-18 labeling studies. Based on… (More)
DOI: 10.1073/pnas.0804279105


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