Mechanism of analgesic action of intrathecal sufentanil.

@article{Ferouz1998MechanismOA,
  title={Mechanism of analgesic action of intrathecal sufentanil.},
  author={F. Ferouz and M. Norris},
  journal={Anesthesia and analgesia},
  year={1998},
  volume={87 5},
  pages={
          1211
        }
}
We read the recent report by Gage et al. (1) with interest. Their results agree with our previously published study showing that hyperbaric intrathecal sufentanil injected in laboring women in the sitting position produces significantly less pain relief and pruritus than isobaric sufentanil (2). The authors conclude that the “addition of dextrose to intrathecal sufentanil limits the spread of adequate concentrations of sufentanil in the low thoracic region of the spinal cord” and, therefore… Expand

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TLDR
The authors conclude that the addition of dextrose to intrathecal sufentanil injected into patients in the sitting position reduces the duration of analgesia without significantly reducing side effects with the exception of pruritus, and therefore does not improve the clinical utility of intratanil. Expand
Baricity, Needle Direction, and Intrathecal Sufentanil Labor Analgesia
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Little or no labor analgesia developed for patients receiving sufentanil with dextrose, suggesting that a supraspinal action may contribute to intrathecal sufENTanil's analgesic efficacy. Expand
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